How a handful of tiny RNA gives women better immune systems

There ’s a longstanding feeling that , on mediocre , char are healthy than adult male , and with good reason . woman survive longer , and study reveal women fight off disease well than their male counterpart . But where does this advantage come from ? Turns out it ’s all thanks to some microRNA on the tenner - chromosome .

At least , that ’s the finding of Dr. Claude Libert of Belgium ’s Ghent University , who has name the specific pieces of RNA that confer this heightened resistant system to women . Like its better bang relative DNA , RNA is essential to the organization of life , and it ’s responsible for for carrying genetic information throughout the cell to channelize various biological reactions and expression of cistron . Very short strands of RNA are know as microRNA , and a lot of these clump in the X - chromosome , which is the female sex chromosome .

Dr. Libert explains :

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“ Statistics show that in man , as with other mammals , females live longer than male and are more able to agitate off shock episode from sepsis , infection or trauma . We trust this is due to the ex chromosome which in humans contains 10 % of all microRNAs find so far in the genome . The theatrical role of many continue unsung , but several X chromosome - place strands of microRNA have important functions in immunity and cancer .

Libert and his team develop a mathematical function of all known microRNA in the X - chromosome that are known to affect the immune system . The came to the conclusion that there is indeed a warm link between the familial material discover in the decade - chromosome and the larger subroutine of the immune organization , and that the reason behind the grammatical gender difference is a phenomenon screw as factor silence . In this appendage , genes are essentially switch over off , so that they ca n’t pass on whatever benefit or damage they might commonly confer . This sham the microRNA in the XTC - chromosome , silence many of the Strand most useful to the immune organisation .

Because women have two XTC - chromosomes , they are good able to compensate for this lose genetic information . Even if lot of these immune - pertain string are silenced , there ’s still a staring set of duplicate that hopefully can remain active and supply this heightened resistant answer . Men , on the other hand , have to make do with what the Y - chromosome can supply – and its supply of helpful microRNA is far too dispirited to be of much function .

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